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Chemokine ligand 4 (CCL4) is a small cytokine belonging to the CC chemokine family that is commonly known as MIP-1 beta. There are at least 27 distinct members of the C-C subgroup reported for mammals. They are characterized by two adjacent cysteines. CC chemokines induce the migration of monocytes and other cell types such as NK cells and dendritic cells. CCL4 (MIP-1 beta) is a chemoattractant for natural killer cells, monocytes and a variety of other immune cells. CCL4 is involved in several inflammatory and autoimmune diseases including viral infection such as HIV-1/AIDS.
Alternate Names - CCL4L1, AT744.2, CCL4L, LAG-1, LAG1, SCYA4L, SCYA4L1, MIP-1-beta, SCYA4L2, C-C motif chemokine ligand 4 like 1
CCL4 Homology Across Species
Macaca fascicularis (cynomolgus monkey) CCL4 – 100%
Macaca mulatta (Rhesus monkey) CCL4 – 100%
Papio anubis (olive baboon) CCL4 – 100%
Chlorocebus sabaeus (green monkey) CCL4 – 99%
Gorilla gorilla gorilla (western lowland gorilla) CCL4 – 99%
Nomascus leucogenys (northern white-cheeked gibbon) CCL4 – 99%
Pongo abelii (Sumatran orangutan) CCL4 – 99%
Rhinopithecus roxellana (golden snub-nosed monkey) CCL4 – 99%
Mandrillus leucophaeus (drill) CCL4 – 98%
Aotus nancymaae (Ma's night monkey) CCL4 – 97%
Callithrix jacchus (white-tufted-ear marmoset) CCL4 – 97%
Cercocebus atys (sooty mangabey) CCL4 – 97%
Colobus angolensis palliates (Peter’s Angolan Colobus) CCL4 – 97%
Macaca nemestrina (pig-tailed macaque) CCL4 – 97%
Rhinopithecus bieti (black snub-nosed monkey) CCL4 – 97%
Saimiri boliviensis boliviensis (Bolivian squirrel monkey) CCL4 – 97%
Homo sapiens (human) CCL4 – 96%
Pan paniscus (pygmy chimpanzee) CCL4 – 96%
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